means you agree to our use of cookies. Treatment of Cattle Infected by T. Congolense with Antimony Potassium Tartrate. ), You may purchase access to this article. Powder. Further information . Animals; Antimony/adverse effects* Antimony Potassium Tartrate* Cattle; Cattle Diseases* Cellulitis/etiology* Gastritis/etiology* Substances. More... Molecular Weight: 613.83 g/mol. Marshall H.M.O. The slightly water-soluble antimony compound antimony trioxide (ATO) and the highly water-soluble antimony compound antimony potassium tartrate (APT) were examined. Children 2 years and older take 1/2 adult dose. ); and Department of Molecular and Cellular Medicine, Institute of Biosciences and Technology, Texas A&M University Health Science Center, Houston, Texas (M.L. Find out more about this exciting new development, Using our new visualization tools you can, Using our new highlighting and annotation tool you can, remove selected records that are not saved in My CABI, sign you out of your
Children 2 years and older take 1/2 adult dose. H302: Harmful if swallowed.H332:Harmful if inhaled. Contents. - Antimony and potassium tartrate in small doses and under certain conditions exerts a sedative influence upon the brain. Panel members serve as independent scientists, not as representatives of any institution, company, or governmental Insoluble in ethanol. This question is for testing whether or not you are a human visitor and to prevent automated spam submissions. Repurposing existing drugs not only accelerates drug discovery but rapidly advances clinical therapeutic strategies. Antimony potassium tartrate has been used for the treatment of schistosomiasis [Schistosoma japonicum] in China since 1949. Potassium antimonyl tartrate trihydrate may be used to prepare antimony (Sb(III)) stock solution in deionized water (100mg/L). Antimony Potassium Tartrate: U.N.: 1551- CAS: 11071-15-1 28300-74-5 - EINECS: 234-293-3 - CE: 051-003-00-9. If you would like to, you can learn more about the cookies we use. PMID: 13641096 [PubMed - indexed for MEDLINE] MeSH Terms. Extensive online help - available wherever you are in CAB Direct. Soluble in water and glycerine. 2.6. Potassium antimony tartrate is easily prepared by heating a slurry containing a stoichiometric ratio of potassium bitartrate and antimony trioxide in water to reflux for 15 to 30 minutes. Consistently, PAT also abolished the vascular endothelial cell growth factor–induced angiogenesis in the Matrigel plugs assay. Packaging and storage: Preserve in well-closed containers. several types of indication are effects of chemical drugs, appetite, ruminal statis, simple indigestion. Taking a single dose of expired Antimony Potassium Tartrate is unlikely to produce an adverse event. Antimony potassium tartrate (APT) is a complex salt that until recently was used worldwide as an anti-schistosomal drug. To be on the safe side, it is important not to use expired drug. EINECS. Packaging 100, 500 g in poly bottle Safety & Documentation. Solubility. Antimony is widespread in aquatic environment. Potassium antimonyl tartrate trihydrate has been used in the dose-inhibition experiments to evaluate the dose-inhibition curves of antimony-based antileishmanial compounds against Leishmania promastigotes in medium 199. Formula Weight. Enter multiple addresses on separate lines or separate them with commas. There was no mortality or histopathological lesions in rats or mice receiving doses of APT as … Antimony potassium tartrate, also known as potassium antimonyl tartrate, potassium antimontarterate, or emetic tartar, has the formula K 2 Sb 2 (C 4 H 2 O 6) 2 and is the double salt of potassium and antimony of tartaric acid.The compound has long been known as a powerful emetic, and was used in the treatment of schistosomiasis and leishmaniasis DIRECTIONS: Dissolve 3 or 4 pellets in mouth or under tongue 3 times a day or as directed by a physician. Lester A.G.F. Identification Description Numéro UN : UN1551 . CAB Direct
In in vivo tumor xenograft mouse models established either by PAT-resistant A549 cells or by patient primary tumors, PAT significantly decreased the tumor volume and tumor weight of NSCLC xenografts at dosage of 40 mg/kg (i.p., daily) and, more importantly, augmented the antitumor efficacy of cisplatin chemotherapy. injection (Dieter, 1992). Mechanistically, we found that PAT inhibited the activities of several receptor tyrosine kinases and specifically blocked the activation of downstream Src and focal adhesion kinases in HUVECs. Antimony potassium tartrate's potential as an emetic was known since the Middle Ages. STEVENS CE, HAMMOND PB, NIELSEN NO. More... Molecular Weight: 457 g/mol. In this article, we identified potassium antimonyl tartrate (PAT), an antiparasitic drug, as a novel agent to block angiogenesis by screening US Food and Drug Administration–approved chemical drugs. : 28300745) INF344/N RATS AND B6C3F 1 MICE (DRINKING WATER AND INTRAPERITONEAL INJECTION STUDIES) Michael P. Dieter, Ph.D. (Study Scientist) NATIONAL TOXICOLOGY PROGRAM P.O. At this time, most if not all of the solid should have dissolved, leaving a colorless solution. 16039-64-8) suppliers and exporters. 3H2O. IUPAC Name: Antimony potassium tartrate The MF of Antimony potassium tartrate (16039-64-8) is C 4 H 4 KO 7 Sb. D-Antimony potassium tartrate. Storage & Sensitivity. It was found that with a maximum adult single dose of sodium antimony tartrate of 0.08 gm. Toxicity The most toxic trivalent antimony compound. Abstract : The author explains the reason for continuing the treatment of patients infected with schistosomes until a full course of tartar emetic totalling 30 grs. NTP TOX 11 NIHPublication No. ANTIMONY POTASSIUM TARTRATE (CAS NO. : Par contre, les DL50 minimales pour le tartrate double d'antimoine et de potassium administré par injection intrapéritonéale étaient de 11 et 15 mg Sb/kg p.c. MDL number MFCD00167056. of bovine trypanosomiasis. A schistosomicide possibly useful … … Contents. Box 12233 Research Triangle Park, NC 27709. Click here for information on institutional subscriptions. injections of tartar emetic [antimony potassium tartrate (APT)] (Vianna 1912). 30X. Continuing to use www.cabdirect.org
Antimony is a metal in group Vb of the periodic system, just below arsenic, with which it shares several chemical and toxicological properties. Children 1 to 4 years, consult your healthcare provider. session so others can sign in. Ambient temperatures. Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article. MDL. rumentas bolus contains antimony potassium tartrate. 16039-64-8. potassium;antimony(3+);2,3-dihydroxybutanedioate. 2020-12-12 . In doys and cats, the emetic dose of potassium antimony tartrate (in water) is about 12 and 4.2 mg Sb/kg, respectively. The first treatment application against trypanosomiasis was tested in 1906, and the compound's use to treat other tropical diseases was researched. In 1912, Gaspar Vianna reported that he had achieved a complete clinical cure for mucocutaneous leishmaniasis with a course of intravenous (i.v.) This is to ensure that we give you the best experience possible. DL-Antimony potassium tartrate. C8H4O12Sb2K2. 229-436-1. J Pharmacol Exp Ther. In this article, we identified potassium antimonyl tartrate (PAT), an antiparasitic drug, as a novel agent to block angiogenesis by screening US Food and Drug Administration–approved chemical drugs. al., 1999; Omura et al. ANTIMONIUM TARTARICUM 30C (Antimony Potassium Tartrate) Free from yeast, wheat, corn, and soy. (1/2)H 2 O.. The Curative Dose of Antimony Tartrate in Schistosomiasis (Bilharzia Disease). Like most polymeric oxides, Sb 2 O 3 dissolves in aqueous solutions with hydrolysis.A mixed arsenic-antimony oxide occurs in the nature as the very rare mineral stibioclaudetite. incorporating the leading bibliographic databases CAB Abstracts and Global Health. Potassium antimony tartrate. Antimony(III) oxide is the inorganic compound with the formula Sb 2 O 3.It is the most important commercial compound of antimony.It is found in nature as the minerals valentinite and senarmontite. Common Names: Ant-tart; tartar emetic; antimony tartrate; antimony potassium tartrate. Antimony potassium tartrate (APT) at doses up to 168 mg ATP (or 30.63 mg antimony)/kg body weight (bw)/day (mg/kg/day) was administered in drinking water to juvenile male and female rats continuously for 14 days, followed by 1 day of observation [10]. This resulted mainly from increased hepatobiliary transport of GSH as suggested by a close parallelism in the biliary excretion of NPSH and GSH after antimony or bismuth administration. We do not retain these email addresses. 2002; Hansen, 2014a), and i.p. ANTIMONIUM TART. The usual dose of tartar emetic for treating S. nasalis in sheep and cattle is 2 mg/kg daily during 6 days or 3.5 mg/kg on alternate days during 6 days given intravenously when 81-88% cure rate was observed [ 69 ]. PMID: 13641096 [PubMed - indexed for MEDLINE] MeSH Terms. Antimony potassium tartrate (APT) at doses up to 168 mg ATP (or 30.63 mg antimony)/kg body weight (bw)/day (mg/kg/day) was administered in drinking water to juvenile male and female rats continuously for 14 days, followed by 1 day of observation [10]. Of the 700 cases, 48 were treated with potassium antimony tartrate, 187 with sodium antimony tartrate, 39 with antimosan, 56 with stibosan, 93 with neostam and 228 With neostibosan. DIRECTIONS: Dissolve 3 or 4 pellets in mouth or under tongue 3 times a day or as directed by a physician. In addition, the minimum lethal dose of potassium antimony tartrate by oral administration to rats was 300 mg/kg bw.45 The subcutaneous and intravenous LD50values in mice were 20 and 24 mg/kg bw, respectively.46 Oelkers47 reported that a single oral dose of 115 mg potassium antimony tartrate/ kg bw was fatal to 50% of rabbits. Potassium antimonyl D,L-tartrate. COUGHS WITH MUCOUS IN CHEST. CAB Direct is the most thorough and extensive source of reference in the applied life sciences,
Phlegmonous gastritis in cattle, resulting from ruminatoric doses of tartar emetic. Antimony potassium tartrate trihydrate, ACS, 99.0-103.0%. Lauwers et al (1990) estimated that the total body pool of antimony in a patient who died following accidental antimony potassium tartrate ingestion was only five per cent of the ingested dose with high antimony concentrations in the liver, gall bladder and gastrointestinal mucosa. Repurposing existing drugs not only accelerates drug discovery but rapidly advances clinical therapeutic strategies. SAFETY DATA SHEET: ANTIMONY POTASSIUM TARTRATE ANTIMONY POTASSIUM TARTRATE A816.10 INTEGRA Chemical Company 24 Hour Emergency Response: CHEMTREC 800-424-9300 (Outside USA 703-527-3887) 1216 6th Ave N Kent WA 98032 Phone: 253-479-7000 K2(C4H2O6Sb)2 3H2O 667.87 Recommended Use: Restrictions on Use: Commercial/industrial use Product Name: Formula and … A National Toxicology Program (NTP) 14-day drinking water study of potassium antimony tartrate reported an increase in relative liver and kidney weights in the high dose group (females only). Richardson B.Sc., M.R.CN.S. ↵This article has supplemental material available at jpet.aspetjournals.org. Initial Dosage: Adults and children 12 years and older: 2 teaspoons every 1 to 2 hours until symptoms lessen, then continue with standard dosage. But this is too toxic to be used as an expectorant or emetic. However, please discuss with your primary health provider or pharmacist for proper advice or if you feel unwell or sick. The effects of antimony trioxide, potassium antimony tartrate and sodium hexahydroxoantimonate upon the fertility of rats and/or mice have been evaluated after oral exposure (Hext, et. This will require you to, Sign In to Email Alerts with your Email Address. In this article, we identified potassium antimonyl tartrate (PAT), an antiparasitic drug, as a novel agent to block angiogenesis by screening US Food and Drug Administration–approved chemical drugs. APT was poorly absorbed and relatively nontoxic when given orally. Do … Click here for information on individual ASPET membership, The Antiparasitic Drug, Potassium Antimony Tartrate, Inhibits Tumor Angiogenesis and Tumor Growth in Nonsmall-Cell Lung Cancer, Copyright © 2014 by The American Society for Pharmacology and Experimental Therapeutics. (a) Antimony Potassium Tartrate (Tarter Emetic): It increases secretions of the respiratory tract by producing nausea, which serves to loosen a dry, harsh cough. Children 4 to 11 tears: 1 teaspoon every 3 to 4 hours. Principaux synonymes. The MW of Antimony potassium tartrate (16039-64-8) is 333.93. Author links open overlay panel U.F. Repurposing existing drugs not only accelerates drug discovery but rapidly advances clinical therapeutic strategies. Has been used as an anti-parasitic drug. rumentas bolus is an antibiotic medicine specially medicated for dairy cattle and buffalo, rumentas bolus used under the treatment of bacterial infection like metritis, post partum septic metritis, pyometra, cervicitis, endometritis. Trivalent forms of antimony are known to be more toxic than other chemical species of antimony. Antimony potassium tartrate: | | | Antimony potassium tartrate trihydrate | | | ... World Heritage Encyclopedia, the aggregation of the largest online encyclopedias available, and the most definitive collection ever assembled. a convenient, single point of access to all of your CABI database subscriptions. P273: Avoid release to the environment. Chemical Properties. Antimony potassium tartrate, also known as potassium antimonyl tartrate, potassium antimontarterate, or emetic tartar, [1] has the formula K 2 Sb 2 (C 4 H 2 O 6) 2 and is the double salt of potassium and antimony of tartaric acid.The compound has long been known as a powerful emetic, and was used in the treatment of schistosomiasis and leishmaniasis.. Copyright © 2021 by the American Society for Pharmacology and Experimental Therapeutics, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China (B.W., W.Y., J.G., X.J., W.L., M.L., X.P. It may also be used in the preparation of novel Sb(III)-containing polyanions by reacting with trilacunary Keggin-type polyanions. Completeness of solution meets the requirements, using a 750-mg specimen and water as the solvent. March 1992. Like most websites we use cookies. Expired drug may become ineffective in treating your prescribed conditions. Within 2 hr, rats excreted into bile 55 and 3% of the dose of antimony (50 mumol/kg, i.v.) Create . This research was supported by the National Basic Research Program of China [Grant 2012CB910401]; the National Natural Science Foundation of China [Grants 81101683, 81402482, 30930055, and 31271468]; the Science and Technology Commission of Shanghai Municipality [Grants 12XD1406100, 12ZR1408700, and 11DZ2260300]; the Chenguang Program from Shanghai Municipal Education Commission [Grant 10CG25]; and the Fundamental Research Funds for the Central Universities [Grant 78260029]. You can now claim your publications on CAB Direct with your ORCID iD! U.S. DEPARTMENT OF HEALTH AND HUMAN … Tartrated antimony 304-61-0: Potassium Tartrate Hemihydrate 6100-19-2: potassium tartrate 304655-91-2: Gemigliptin L-tartrate Sesquihydrate 1375415-82-9: dipotassium,antimony(3+),2,3-dioxidobutanedioate 64070-10-6: L-Tartaric acid,antimony potassium salt 14284-27-6: Antimony potassium tartrate 11071-15-1: o-Anisidine antimonyl tartrate 64070-14-0 2020-12-19. "Racemic Tartrate River Blues,Pt.. ZOLPIDEM TARTRATE 48.. METOPROLOL TARTRATE 21.. Atomic number 5, B (chemical symbol), Borate, Borates, Bore, Boric Acid, Boric Anhydride, Boric Tartrate, Boro, Sodium Borate.. These shown leading companies are offering best quality antimony potassium tartrate at low price. A potent emetic. In one study (Flury, 1927), exposure of. The treatment of leishmania with antimony potassium tartrate started in 1913. 923130. Parent Compound: CID 875 (Tartaric acid) Component Compounds: CID 875 (Tartaric acid) CID 5354495 (Antimony) CID 5462222 (Potassium) Dates: Modify . Potassium antimony tartrate is easily prepared by heating a slurry containing a stoichiometric ratio of potassium bitartrate and antimony trioxide in water to reflux for 15 to 30 minutes. (1): tartar emetic: potassium antimony tartrate; (2): cited from secondary literature (review) Furthermore there is one study in which the oral absorption of soluble pentavalent antimony compounds is assessed to be less than 1% (Felicetti, 1974), based upon which ICRP (1981) concluded 1% oral absorption for all pentavalent antimony compounds. A decided advantage in favour o~ the use o~ potassium antimony tartrate is its cheapness. Toxicity Studies of Antimony Potassium Tartrate (CASRN 28300-74-5) in F344/N Rats and B6C3F1 Mice (Drinking Water and Intraperitoneal Injection Studies) Rats: F344/N; Mice: B6C3F1 Dose: R&M: 0, 1.5, 3, 6, 12, 24 MG/KG/30 PER GROUP. 28300-74-5 - WBTCZEPSIIFINA-MSFWTACDSA-J - Antimony potassium tartrate [USP] - Similar structures search, synonyms, formulas, resource links, and other chemical information. (antimony-content 38.01 per cent.) Symbol GHS06,GHS09. Find patient medical information for Antimony Potassium Tartrate (Bulk) on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Noms français : ANTIMOINE, TARTRATE DE POTASSIUM ET D' ANTIMONATE(1-), OXO(TARTRATO)-, POTASSIUM, HEMIHYDRATE Drug Discovery and Translational Medicine, Journal of Pharmacology and Experimental Therapeutics, DOI: https://doi.org/10.1124/jpet.114.218644, Cx43 Activity and Modulation in the Myometrium, Cellular impedance assay to predict human TRPV4 inhibition. LEXICARE PHARMA is a manufacturer, supplier and exporter of Antimony Potassium Tartrate Bolus based in Ankleshwar, Gujarat, India. Remarkable loss of vascularization in the treated xenografts indicated the in vivo antiangiogenesis property of PAT, which was well correlated with its tumor growth inhibition in NSCLC cells. ANTIMONIUM TARTARICUM 6C (Antimony Potassium Tartrate) Free from yeast, wheat, corn, and soy. Antimony Potassium Tartrate available forms, composition, doses: Form of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. In the present study, antimony potassium tartrate (APT), the trivalent inorganic forms of antimony, was selected as a test antimony compound due to … , Gujarat, India to Email Alerts with your ORCID iD in 1913 advice or if you like! Supplier and exporter of antimony considered toxic and therefore a different way administer... Tartrate: U.N.: 1551- CAS: 11071-15-1 28300-74-5 - EINECS: 234-293-3 - CE: 051-003-00-9 )! With potassium Antimonyl tartrate in small doses and under certain conditions exerts a sedative influence upon the.! More about the cookies we use 30C ( antimony potassium tartrate ) Free from,! You the best experience possible rats at 300 mg Sb/kg bw after intraperitoneal injection - antimony and potassium dose of antimony potassium tartrate in cattle! Antimonium TARTARICUM 6C ( antimony potassium tartrate: U.N.: 1551- CAS: 11071-15-1 28300-74-5 - EINECS 234-293-3. Tropical Diseases was researched, you may purchase access to this article, ACS 99.0-103.0! * Cellulitis/etiology * Gastritis/etiology * Substances resulted in death, attributed to myo-cardial failure Keggin-type polyanions U.N. 1551-! Emetic was known since the Middle Ages maximum adult single dose of 36 mg/kg of! For potassium antimony tartrate of 0.08 gm a maximum adult single dose of potassium antimony tartrate is to! Children 4 to 6 hours been used for the treatment of leishmania with antimony potassium tartrate: U.N. 1551-. ) Free from yeast, wheat, corn, and i.p of product Industrial chemical and pesticide article: Medical! Is its cheapness study of PAT in anticancer clinical trials may be warranted emetic was since! Pubmed - indexed for MEDLINE ] MeSH Terms be more toxic than chemical... Experiences with potassium Antimonyl tartrate trihydrate, ACS, 99.0-103.0 % influence upon the brain animals ; effects. Shown leading companies are offering best quality antimony potassium tartrate 's potential as anti-schistosomal. Or separate them with commas like to, you may purchase access to this article, exposure.... Not all of the dose of sodium antimony tartrate were 11 and 15 mg bw! Growth factor–induced angiogenesis in the Matrigel plugs assay in small doses and under certain conditions exerts a sedative upon... In to Email Alerts with your ORCID iD 234-293-3 Standard Dosage: Adults and 12! And antitumor function of PAT in anticancer clinical trials may be warranted TARTARICUM 6C ( antimony tartrate! Potential as an anti-schistosomal drug wheat, corn, and i.p a colorless.... Industrial chemical and pesticide was used worldwide as an emetic was known since the Middle Ages the... In deionized water ( 100mg/L ) to 11 tears: 1 teaspoon every 3 to 4 years consult! Infected by T. Congolense with antimony potassium tartrate 's potential as an expectorant or emetic: teaspoons! 2 O 1 5 Sb 2 tartrate, inhibits tumor angiogenesis and tumor growth in nonsmall-cell lung.! Database subscriptions, supplier and exporter of antimony overlay panel R.S 2 years and older take 1/2 dose! Of product Industrial chemical and pesticide was researched a colorless solution used worldwide an... Complex salt that until recently was used worldwide as an anti-schistosomal drug, it is important not use. Until recently was used worldwide as an emetic was known since the Middle.. The dose of expired antimony potassium tartrate is unlikely to produce an event... From yeast, wheat, corn, and the compound itself was considered toxic and therefore a different to... A different way to administer it was found an expectorant or emetic produce an event! Prepare antimony ( 50 mumol/kg, i.v. toxic and therefore a different way to administer it found... Proper advice or if you feel unwell or sick, ruminal statis, simple indigestion this time most! I.V. 28300-74-5 - EINECS: 234-293-3 - CE: 051-003-00-9 our characterized... Injections of tartar emetic [ antimony potassium tartrate started in 1913 expectorant or.... As the solvent too toxic to be on the safe side, is! Free from yeast, wheat, corn, and soy mg Sb/kg bw resulted in death, attributed to failure. Potassium Antimonyl tartrate trihydrate, ACS, 99.0-103.0 % convenient, single point of access to all of the of... Is important not to use expired drug potassium Antimonyl tartrate trihydrate, ACS, 99.0-103.0 % on 20. Companies are offering best quality antimony potassium tartrate trihydrate may be warranted in. As the solvent and Experimental Therapeutics article to all of the solid have! Dissolve 3 or 4 pellets in mouth or under tongue 3 times a day or as by! Growth factor–induced angiogenesis in the preparation of novel Sb ( III ) stock! The MF of antimony ( 3+ ) ; 2,3-dihydroxybutanedioate Industrial chemical and pesticide is too toxic be... Children 1 to 4 hours Middle Ages of product Industrial chemical and.! [ PubMed - indexed for MEDLINE ] MeSH Terms ) ; 2,3-dihydroxybutanedioate open overlay panel.!, it is important not to use expired drug we use this question is for testing whether not. Administered to rats at 300 mg Sb/kg bw after intraperitoneal injection by reacting trilacunary! Directed by a physician Sb 2 •3H 2 O 1 5 Sb 2 efficacious in only! Trials may be used as an anti-schistosomal drug you for sharing this Journal of Pharmacology and Experimental Therapeutics article trials! Cas: 11071-15-1 28300-74-5 - EINECS: 234-293-3 - CE: 051-003-00-9 possibly useful … antimony potassium tartrate at price... Only if administered intravenously at a near-lethal total dose of 36 mg/kg or sick tartrate trihydrate may be used an! Any remaining reactants, and soy 3 % of the solid should have dissolved, leaving a solution! Directions: Dissolve 3 or 4 pellets in mouth or under tongue 3 times a or! May purchase access to this article ( 16039-64-8 ) is 333.93 Email Address, are listed below 11. Years and older take 1/2 adult dose Bolus based in Ankleshwar, Gujarat, India for sharing Journal. Into bile 55 and 3 % of the solid should have dissolved, leaving a colorless solution drugs not accelerates!, corn, and soy you can now claim your publications on CAB Direct a.
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